World leaders from more than 20 nations gathered in Egypt to formally sign the agreement, which Egyptian President Abdel Fattah El-Sisi called "the birth of a glimmer of hope" for the region.

In South Carolina, more than 150 unvaccinated schoolkids are under quarantine after being exposed to measles. Across the U.S., total case counts could be even higher than the official number.

On Saturday, a federal appeals court blocked the Trump administration from deploying federalized National Guard troops in Illinois.

With no end in sight to the funding standoff, financial anxiety is growing. One single mom in Colorado raided her retirement savings to get through the shutdown.

If Congress doesn't act, costs will rise on premiums for health care plans on the Affordable Care Act marketplaces. Here's what to know about the politics and real-world impact of this issue.

Preparations were also underway Sunday for the release of Israeli hostages held in Gaza and Palestinian prisoners held in Israel.

A blast in rural Tennessee that leveled an explosives plant and was felt for miles around killed 16 people and left no survivors, authorities said.

Sources tell NPR that more than 100 employees have been laid off at the Substance Abuse and Mental Health Agency. The Centers for Disease Control and Prevention had some cuts reversed late Saturday.

The 120-pound eastern black rhino has yet to be named.